It is very possible to get most (if not all) achievements/trophies on a single playthrough. You can also get nearly all augmentation upgrades too.
The single most important strategy is to: Play on Hard and stealth takedown every target you can.
More specifically, I would recommend spending your first few Praxis points on the following augmentations
- Cybernetic Arm Prosthesis, Move/Throw Heavy Objects
- Hacking Capture, Capture 2
- Hacking Capture, Capture 3
- Hacking Fortify, Fortify 1
- Hacking Fortify, Fortify 2
- Hacking Fortify, Fortify 3
- Reflex Booster
If you were able to takedown every Purity First enemy, obtain the Smooth Operator and Ghost experience bonuses, and hack every terminal up until Zeke Sanders, then you should be getting your first level up, and another Praxis point to spend! Begin popping these into Capture and Fortify augmentations. Hacking terminals and doors are a great way to earn additional experience, and there are many doors and terminals in DE:HR :)
Lastly, I mention Reflex Booster. This is a great augmentation, and you should get this before engaging any hostiles in Detroit. Not only does it look incredibly cool to takedown 2 opponents simultaneously, but there is also a nice little experience bonus awarded for it!
By the time you leave Detroit, you will likely have been everywhere, have everything, and have all augmentations that you actually need to complete the game. For instance, Capture 1-5, Fortify 1-3, Reflex Booster, some stealth, and maybe some inventory, depending on how you choose to spend your points. Yep, there is that much experience to be had in Detroit.
Happy hunting!
